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Year : 2014? |? Volume : 3? |? Issue : 1? |? Page : 17-20 |
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Status of salivary iron in oral cancer and oral potentially malignant disorders
Shishir Ram Shetty1, Subhas Babu1, Suchetha Kumari2, Pushparaja Shetty3, Shruthi Hegde1, Renita Castelino1
1?Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Science, Nitte University, Mangalore, Karnataka, India
2?Department of Biochemistry, KS Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India
3?Department of Oral Pathology, AB Shetty Memorial Institute of Dental Science, Nitte University, Mangalore, Karnataka, India
Correspondence Address:
Shishir Ram Shetty
Reader, Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Nitte University
India
DOI: 10.4103/2278-9588.130432
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Introduction: Iron (Fe) is an important micronutrient which is utilized in human body for the transportation of oxygen, hematopoiesis, production of enzymes, and immune surveillance. Existing clinical, epidemiological, and experimental studies have shown that decreased levels of Fe contribute to increased risk of cancer. Although extensive, serum Fe analysis studies have done recently the analysis of salivary Fe has not been studied for its role in oral malignancies. Materials and Methods: Salivary Fe levels were evaluated in 65 healthy controls (HC), 115 subjects with oral potentially malignant disorders, and 50 subjects with oral squamous cell carcinoma using the bathophenanthroline method. Results: A decrease in the levels of salivary Fe was observed in subjects with potentially malignant disorders and subjects with oral cancer. The decrease in the salivary Fe was significant (P = 0.05) in group comprising of potentially malignant disorders and oral squamous cell carcinoma when compared to HC. Conclusion: The significant and encouraging findings of the present study thus validate and reinforce that; salivary Fe analysis can be used as an efficient, noninvasive, patient-friendly tool for the early diagnosis of oral potentially malignant disorders and oral squamous cell carcinoma for planning comprehensive treatment protocol. |
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